Info Icon
Please note: All Prescription drugs require a prescription from the prescriber prior to shipment.

Simparica TRIO Chewable Tablets rx


Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis (black-legged tick) for 5 weeks (35 days), and with Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick) for 4 weeks (28 days). For the treatment and prevention of flea infestations for 5 weeks (35 days); Simparica Trio kills adult fleas. For the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections.


Dogs and Puppies (8 weeks of age and older and weighing 2.8 lbs or more)



Active ingredient(s):

Sarolaner, Moxidectin, Pyrantel

Side Effects:

Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. This class has been associated with neurological adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurological disorders. Some possible side effects of taking Simparica Trio may include : vomiting, diarrhea, lethargy, anorexia, polyria, hyperactivity or polydypsia.


Not for human use. Keep away from children and animals. The safe use of SIMPARICA TRIO has not been evaluated in breeding, pregnant, or lactating dogs. Prior to administration of SIMPARICA TRIO dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. SIMPARICA TRIO is not effective against adult D. immitis.

In case of Overdose:

Contact your nearest emergency animal hospital.


Store at or below 30*C (86*F)

Dosage and Administration :

The recommended minimum dosage is 1.2 mg/kg (0.54 g/lb) sarolaner, 24 µg/kg (0.011 mg/lb) moxidectin, and 5 mg/kg (2.27 mg/lb) pyrantel (as pyrantel pamoate). 
SIMPARICA TRIO is given orally on a monthly basis. SIMPARICA TRIO needs to be administered every 4 weeks in case of exposure to Amblyomma maculatum, Dermacentor variabilis, and Rhipicephalus sanguineus. In case of tick infestation, accurate tick identification is recommended prior to administering the product.

Body Weight  /  Sarolaner per Tablet (mg)  /  Moxidectin per Tablet (mg)  /  Pyrantel per Tablet (mg)  /  Number of Tablets Administered (1)

2.8 to 5.5 lbs  /              3.0                          /                    0.06                     /                   12.5                                            
5.5 to 11 lbs   /              6.0                          /                    0.12                     /                    25                                                 
11-22 lbs       /               12                          /                    0.24                      /                   50                                                
22-44 lbs      /                24                          /                    0.48                     /                   100                                                
44-88 lbs      /                48                         /                     0.96                     /                   200                                                
88-132 lbs    /                72                         /                     1.44                     /                   300                                                  
SIMPARICA TRIO can be offered to the dog with or without food.
Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If a monthly dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing.

Active Ingredients : Sarolaner, Moxidectin, Pyrantel

Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease, control of flea and tick infestations, treatment and control of roundworm and adult hookworm infections.


Write a review

21 other products in the same category: