When pets can’t adapt to stress, it can lead to hyperactivity, abnormal urine marking, excessive scratching, trembling, pacing, excessive panting and destructive or aggressive behavior.

Fluoxetine is an antidepressant belonging to a group of drugs called selective serotonin reuptake inhibitors (SSRI). Fluoxetine requires a prescription from your veterinarian.

Amitriptyline is a tricyclic antidepressant. It's used to treat certain behavioral problems, such as separation anxiety, fear of noises, and anxiety in dogs, and urinating out of the litter box, spraying, and anxiety in cats. Amitriptyline requires a prescription from your veterinarian.